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Mutational dynamics and transmission properties of SARS-CoV-2 superspreading events in Austria

Popa A*, Genger J-W*, Nicholson MD+, Penz T+, Schmid D+, Aberle SW+, Agerer B+, Lercher A+, Endler L, Colaco H, Smyth M, Schuster M, Grau ML, Martinez-Jimenez F, Pich O, Borena W, Pawelka E, Keszei Z, Senekowitsch M, Laine J, Aberle JH, Redlberger-Fritz M, Karolyi M, Zoufaly A, Maritschnik S, Borkovec M, Hufnagl P, Nairz M, Weiss G, Wolfinger MT, von Laer D, Superti-Furga G, Lopez-Bigas N, Puchhammer-Stoeckl E, Allergerger F, Michor F, Bock C, Bergthaler A.

Published in Science Translational Medicine: November 23, 2020.

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Mission Statement

The research of our lab focuses on the evolutionary dynamics of cancer. Cancer emerges due to an evolutionary process in somatic tissue. The fundamental laws of evolution can best be formulated as exact mathematical equations. Therefore, the process of cancer initiation and progression is amenable to mathematical investigation. Current areas of research include cancer stem cells, evolution of drug resistance, and the dynamics of metastasis formation.