DNA secondary structures and epigenetic determinants of cancer genome evolution
Subhajyoti De and Franziska Michor
Published in Nature Structural and Molecular Biology on July 3rd, 2011.
The research of our lab focuses on the evolutionary dynamics of cancer. Cancer emerges due to an evolutionary process in somatic tissue. The fundamental laws of evolution can best be formulated as exact mathematical equations. Therefore, the process of cancer initiation and progression is amenable to mathematical investigation. Current areas of research include cancer stem cells, evolution of drug resistance, and the dynamics of metastasis formation.