Punctuated copy number evolution and clonal stasis in triple-negative breast cancer

Ruli Gao, Alexander Davis, Thomas O McDonald, Emi Sei, Xiuqing Shi, Yong Wang, Pei-Ching Tsai, Anna Casasent, Jill Waters, Hong Zhang, Funda Meric-Bernstam, Franziska Michor & Nicholas E Navin

Published in Nature Genetics August 15, 2016

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Mission Statement

The research of our lab focuses on the evolutionary dynamics of cancer. Cancer emerges due to an evolutionary process in somatic tissue. The fundamental laws of evolution can best be formulated as exact mathematical equations. Therefore, the process of cancer initiation and progression is amenable to mathematical investigation. Current areas of research include cancer stem cells, evolution of drug resistance, and the dynamics of metastasis formation.